- Children should have an adult carer in the household who if HIV positive is receiving Anti-HIV therapy if needed.
- Parents or guardians, and children where appropriate must be willing and able to give informed consent.
- Children must have a documented diagnosis of HIV infection.
- Age 6 months to 12 years (upto 17 years for children from DART households).
- Previously untreated with anti-HIV drugs (other than for the prevention of mother to child transmission).
- Children must fulfil World Health Organisation criteria for starting treatment.
- Cannot, or unlikely to attend regularly.
- Likelihood of poor adherence.
- Presence of acute infection.
- Receiving medication that cannot be taken in combination with anti-HIV drugs.
- Laboratory abnormalities which prevent anti-HIV drugs being taken.
- Girls: Pregnancy or breast-feeding.