ARROW is registered on the International Standard Randomised Controlled Trial Number (ISRCTN) Register, ISRCTN24791884.
ARROW is funded jointly by the Department for International Development (UK) and the Medical Research Council (UK).
ARROW is funded jointly by the Department for International Development (UK) and the Medical Research Council (UK).
ARROW is a randomised controlled clinical trial designed to assess two different management strategies for giving first line anti-HIV medicines.
ARROW has two main aims: to find out whether anti-HIV drugs can be given safely and effectively without doing regular blood tests to monitor how children are doing on HIV treatment; and whether starting children on 4 anti-HIV drugs for a short period of time before continuing with 3 drugs is better over the long term than starting on the standard 3 drugs.
The majority of the tablets being used in ARROW are scored and so can be easily snapped in half, aiding their use in children.
ARROW is taking place in Uganda and Zimbabwe in collaboration with the UK. It aims to recruit a total of 1200 children by the end of 2008 with follow up for a further 31/2 years.
Read more about ARROW in the Trial Summary section
November 2010
Evidence 4 Action (EFA) has published 3 ARROW case studies.
- Improving children’s access to research participation in poorly resourced communities
- Use of scored tablets of first line antiretroviral drugs in HIV-infected children in resource limited settings: Experiences from the ARROW Clinical trial
- Tablets are more acceptable and give fewer problems than syrups among young HIV-infected children in resource-limited settings in the ARROW trial
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